Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity

Y Tayipto; J Rosado; D Gamboa; MT White; B Kiniboro; J Healer; DH Opi; JG Beeson; E Takashima; T Tsuboi; M Harbers; L Robinson; I Mueller; RJ Longley

Journal article

Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity

Y Tayipto, J Rosado, D Gamboa, MT White, B Kiniboro, J Healer, DH Opi, JG Beeson, E Takashima, T Tsuboi, M Harbers, L Robinson, I Mueller, RJ Longley

Frontiers in Cellular and Infection Microbiology | Published : 2022

DOI: 10.3389/fcimb.2022.950909

Download PDF

Abstract

A more sensitive surveillance tool is needed to identify Plasmodium vivax infections for treatment and to accelerate malaria elimination efforts. To address this challenge, our laboratory has developed an eight-antigen panel that detects total IgG as serological markers of P. vivax exposure within the prior 9 months. The value of these markers has been established for use in areas with low transmission. In moderate–high transmission areas, there is evidence that total IgG is more long-lived than in areas with low transmission, resulting in poorer performance of these markers in these settings. Antibodies that are shorter-lived may be better markers of recent infection for use in moderate–hig..

View full abstract

University of Melbourne Researchers

James Beeson Author

Ivo Mueller Author

Rhea Longley Author

Related Projects (2)

CENTRE FOR RESEARCH EXCELLENCE IN MALARIA ELIMINATION

The CRE will work to accelerate progress towards malaria elimination in our region, through Surveillance, to develop better ways to monitor ..

Tropical diseases: Translating discoveries into better health

Major progress being made in control of many infectious diseases occurring in tropical areas, including malaria worms and the bacteria that ..

Grants

Awarded by State Government of Victoria

Funding Acknowledgements

YT received an Australia Award from the Australian Department of Foreign Affairs and Trade to support her Master of Biomedical Science research. This work was supported by an Australian National Health and Medical Research Council (NHMRC) Investigator Grant (#1173210 to RL and #1173046 to JB). The PNG longitudinal cohort study was funded by NIH U19 AI089686. The Peruvian samples were collected under the ICEMR program (U19AI089681). LR was supported by NHMRC grants #1161627 and #1016443. IM was also supported by the NHRMC (grants #1092789, #1134989, #1132975, and #1043345). We acknowledge the support of the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.